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doi: 10.1021/bi00064a021

31 Evaluations of these trials indicate that while some candidates such as sprifermin and BMP-7 have shown promise in improving cartilage thickness or pain relief, many have failed to demonstrate clinically meaningful outcomes due to the heterogeneity of OA and the inadequacy of trial designs

Indeed, other studies have reported the neuroprotective effect of different extracts of B

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