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T-cell death as a barrier to sustained antitumor immunity Beyond functional exhaustion and the complex signaling networks that regulate T-cell activity, the physical elimination of tumor-reactive T cells within the TME represents a criticalyet often overlookedmechanism that limits the durability of antitumor immunity

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Metallo-drugs offer a novel approach to target the integrated proviral DNA within latent reservoirs of HIV, where traditional antiretroviral medications frequently prove ineffective (Pincus et al., 2025)

Opa1 deficiency promotes development of retinal vascular lesions in diabetic retinopathy