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In contrast, the placebo-controlled PANTHEON (Placebo-controlled study on efficAcy and safety of N-acetylcysTeine High dose in Exacerbations of chronic Obstructive pulmoNary disease) study, conducted in Chinese patients with moderate-to-severe COPD, concluded that the reduction of acute exacerbations during NAC treatment, administered at an unapproved high dose (1200 mg/day), was independent of concomitant ICS use [93]

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For instance, Long et al