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[13] Because cagrilintide retains intrinsic calcitonin-receptor agonism alongside amylin-receptor activity, it is most accurately described as a dual amylin/calcitonin receptor agonist rather than a pure amylin analog
The peptide sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) remains stable in gastric acid, which distinguishes it from many other growth factors and healing compounds that degrade rapidly in the digestive system
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It effectively inhibits pro-inflammatory cytokines like TNF-, IL-1, and IL-6 through complex mechanisms that interrupt inflammatory cascades
