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TH+ dopaminergic neurone survival striatum +1822%

doi: 10.1016/j.bbih.2021.100335 125 CussottoSClarkeGDinanTGCryanJF

In opioid-injecting participants, the higher maintenance dose of BUP-XR may improve treatment retention and adherence, and thus, may lead to personal recovery and improved quality of life in this subpopulation

The 12 mg trial dose is rarely described in community references because the GI burden was the rate-limiting factor in the trial

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