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The second trial (NCT02240589) was completed in 2017, but results were inconclusive with the main limitation being small sample size (11 participants)

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Most people tolerate Vitamin B12 injections very well

Advantages: Smaller, easier to use for precise measurements

Supplementary Figure 2 : A) Panel of images of oligodendrocyte (Olig2+ cells) in the CC in vehicle and cpz treated mice

TB-500 is also studied for its anti-inflammatory properties via TLR4/MyD88 pathway modulation and its role in reducing apoptosis in neural and cardiac tissue