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A., & Kopple, J

Pandey SK, Apple DJ, Werner L, Maloof AJ, Milverton EJ

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Prolonged exposure to tobacco smoke, air pollution, pathogens and/or other risk factors submits lungs to a pro-oxidative environment, correlates with a functional decline of the lung epithelium 2,3,4 and can actively contribute to neoplastic transformation

Additionally, congested blood vessels, interstitial congestion, and infiltration of inflammatory cells were observed (Fig