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Medications like omeprazole, cimetidine, lansoprazole, and folate can interfere with B12 absorption

The NHS treatment page lays it out clearly: Loading phase (no neurological symptoms): 1mg every other day for two weeks, or until symptoms stop improving

doi:10.1016/j.euroneuro.2019.10.011 Godos J, Currenti W, Angelino D, et al

Weekly treatments are commonly used to support: Energy and stamina Fat and carbohydrate metabolism Liver function and detoxification Mental clarity and focus Healthy overall metabolic function Because these injections are part of a wellness and lifestyle approach, treatment frequency can vary depending on your goals, baseline vitamin levels, metabolism, lifestyle, and how your body responds to treatment

In the Billon 2023 paper, mice given 30 mg/kg IP still showed measurable plasma and muscle concentrations at 6 hours post-injection, which helps explain why twice-daily dosing was used in efficacy studies

However, if you're using both, be cautious and monitor for irritation, as retinoids can sometimes cause dryness or sensitivity