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For example, a compound demonstrating selectivity at the human MC 3 receptor may not replicate this activity in the mouse ortholog, as it occurs with the peptide 2 MSH (201)

doi: 10.1016/j.athoracsur.2015.02.060 16 ChandranRSPatilAKPrabhakarRBBalachandranK

In the cis orientation the hydrogens are on the same side of the bond
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