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doi: 10.1007/BF00043657

(B) Space filling model of the SARS-CoV-2 M pro dimer (apo form) showing the location of cysteines 156 on the surface and 300 near the dimer interface in the left (pink) protomer (PDB ID 7K3T)

The absence of dendritic cells in MucilAir-HF tissues might have led to the lack of marked inflammatory response to LPS and TNF-, while the lack of macrophages in EpiAlveolar tissues might have impacted the response to Crystalline silica, Amorphous silica, Amiodarone, and LPS given the lack of response in the cytokine/chemokine panel

These advancements show promise for toxicological studies, yet further research is needed to optimize their fine development and application (Papalia et al., 2007

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