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33 AOD-9604 AOD-9604 is a synthetic peptide fragment of human growth hormone, originally investigated for its lipolytic effects and is generally administered subcutaneously

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To investigate the molecular bases during this process, we performed bulk RNA-seq of the KYP-treated or control mice dorsal skin

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SIRT1 deacetylates Sterol Regulatory Element-Binding Protein-1c (SREBP-1c) and Carbohydrate Response Element-Binding Protein (ChREBP), suppressing the expression of their downstream lipogenic genes fatty acid synthase (FAS) and acetyl-CoA carboxylase 1 (ACC1), ultimately inhibiting lipogenesis and mitigating MAFLD