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Description
On re-exposure, the drug-protein conjugate cross-links its IgE which bound to the high-affinity receptor and induces the degranulation of mast cells and basophils, and release of inflammatory mediators that induce urticaria, vasodilatation, increased vascular permeability, edema and bronchoconstriction, leading to cardiovascular failure, bronchospasm and even death 2,10

4b and Supplementary Figs

Thus, neurons are damaged directly at DRG producing a progressive sensory neuronopathy

10.1038/sj.jcbfm.9600263 51 HyderF.RothmanD

Beta-hydoxy-beta-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner

[DOI] [PubMed] [Google Scholar] 114.Yang B, Lin X, Yu N, Gao H, Zhang Y, Liu W
