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Despite the early perception that chaperones are the key players of the HSR, more recent studies argue that HSF-1-mediated thermotolerance is not dependent upon the induction of HSPs

Pousset F, Kalotka H, Durr A, Isnard R, Lechat P, Le Heuzey JY, Thomas D, Komajda M

doi: 10.4103/ijpvm.IJPVM_429_20

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Two patients had mtDNA mutations of similar pathogenicity, and four had mtDNA sequence variants of unclear pathogenicity out of 25 tested children [46]

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