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Cell 84 , 46294644.e9 (2024)

MELATONIN SYNTHESIS AND METABOLISM Melatonin Synthesis Melatonin (N-acetyl-5-methoxytryptamine) is synthesized within the pinealocytes from tryptophan, mostly occurring during the dark phase of the day, when there is a major increase in the activity of serotonin-N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT), responsible for the transformation of 5-hydroxytryptamine (5HT, serotonin) to N-acetylserotonin (NAS) (Figure 1)

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Dig Dis Sci 45:19211928

For a detailed explanation, read our article on NAC Figure 1

T cell assays for non-clinical immunogenicity risk assessment: best practices recommended by the European Immunogenicity Platform