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Therefore, cancer cells not only use FAO to oxidize fatty acids and to derive energy by mitochondria but they also use acetyl-CoA to endogenously synthesize fatty acids in the cytosol using NADPH as key cofactor for anabolic enzymes (Koundouros and Poulogiannis, 2020)

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This limitation is mentioned in the Discussion section

Glycine betaine rather than acting only as an osmolyte also plays a role as regulator in cellular metabolism

Registration number of the article: R000025857, UMIN: UMIN000022552

First, the pilot sample size of current study may limit the statistical power and generalizability of the findings