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Of mice and not men: differences between mouse and human immunology

Tondo L, Miola A, Pinna M, Contu M, Baldessarini RJ

NAD+ is a large molecule that cannot cross cell membranes in its whole form

M.KhutoryanskiyV

In the Xenopus oocyte expression system, it is possible to observe an acute desensitization of DOR on potassium channels (Kir3) elicited by DPDPE without significant internalization measured by surface biotinylation (Celver et al., In contrast, the abolition of rKOR internalization by the S369A substitution also inhibits receptor desensitization on potassium currents (Mclaughlin et al., Those data demonstrate that desensitization and internalization are usually two independent processes although in some situations a close relationship could be evidenced

However, fewer patients may be needed if at-risk populations (e.g