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10.1016/j.freeradbiomed.2012.08.565 [DOI] [PMC free article] [PubMed] [Google Scholar] 176.Jornayvaz FR, Shulman GI

We still do not know the optimal dosage or the most effective route of administration for these peptides in humans

Once neurological symptoms appear, deficiency may already be advanced - but treatment can still be highly effective when started promptly

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9 However, qualitative results (responses to free-text items in this study) show that SMVI was common before This study relies on self-reported diagnosis and recruitment from online support groups that evidence suggests has some limitations

Of interest is also the possible passage of Mps through the bloodbrain barrier and the subsequent effects in this tissue