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However, certain non-enzymatic antioxidants such as glutathione, ubiquinone, albumin, metallothioneins, and uric acid are predominantly produced endogenously (155, 168)

All statistical analyses were performed using GraphPad Prism software (version 8.0.2)

8 The mechanism of action of the active ingredients in Tri-Luma Cream in the treatment of facial melasma is unknown

The glutathione content of the hepatocytes was determined by Ellman`s method using spectrophotometer

doi: 10.1007/s00401-020-02178-y