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The nuclear erythroid factor-2 (Nrf2) is a transcription factor involved in redox responses and modulates anti-inflammatory and cytoprotective systems to ensure cell survival against oxidation in different tissues ( In summary, the mechanism of oxidative stress related to cardiac iron overload in -thalassemia patients involves the interplay of excess iron, increased ROS production, and the resultant cellular damage

GraphPad Prism 6.0 software (La Jolla, CA, USA) was used for statistical analyses

Symptoms include developmental delay, metabolic acidosis and cardiomyopathy [16,17]

What a given dose feels like depends on which of the three arms it leans on, and on the body it lands in

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Discussion In a crowded cellular environment, protein-protein interactions are influenced not only by binding affinity but also by intracellular concentrations and competition from other proteins 36,52,63,64