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The dose might change based on how severe the deficiency is

2 More recent work has clarified one striking pathway: growth hormone signaling activates the MEKERK cascade, which phosphorylates and inactivates the transcription factor PPAR, downregulating fat-specific protein 27 (FSP27, also called CIDEC)

The idea is to use the lowest effective dose to prevent regain without the side effects associated with higher therapeutic doses

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No preclinical data shows that 5-Amino-1MQ produces weight reduction even under ad libitum feeding conditions, meaning animals were allowed to eat freely without caloric restriction

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