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Preclinical studies have showed that PDE inhibitors, such as sildenafil and cilostazol, can decrease tissue pathology, accelerate bacterial clearance, and reduce the time to lung sterilization in M.tb -infected mice when used in combination with standard TB therapy [33]

Thiol-disulfide redox equilibria of glutathione metaboloma compounds investigated by tandem mass spectrometry

In a process called the -glutamyl cycle, GSH is continuously recycled to ensure a steady-state supply in cells

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Given the strong cognitive and behavioral components of chronic tinnitus, the most effective multi-target intervention would likely integrate such a drug combination with established neuromodulatory and psychological therapies

The latter process is promoted by IL-2 receptor- (CD25) loss through endocytosis