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Animal studies have shown that rotenone-induced parkinsonism reduced CoQ10 concentrations in plasma and the striatum with a corresponding decrease in striatal levels of DA, mitochondrial complex I activity and ATP levels, as well as significant increase in B-cell lymphoma 2 (Bcl-2) expression (Abdin and Hamouda, 1999)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Sekhar K.R., Rachakonda G., Freeman M.L

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