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All experimental animals tolerated the test compounds after either intravenous or oral administration and showed no abnormalities or signs of toxicity

L., Srinivasan S

Furthermore, the cell membrane-coated ZIF-8@MnOx nano-platform mPDZM simultaneously loaded with doxorubicin and piperlongumine can effectively promote CD8 + T cell and NK cells infiltration by regulating SASP release, inducing ICD and activating the STING signaling pathway, while reducing Tregs and M2-like macrophages and can further enhance anti-tumor immunity and produce a strong abscopal effect on distant tumors when combinated with anti-PD-L1 therapy (235)

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This eventually led to another FDA approval for the treatment of glabellar lines in 2002

Ikuta, M