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58-54-8 Chemical Name: Ethacrynic acid Synonyms ETACRYNIC ACID;edecrin;mingit;mk-595;reomax;uregit;edecril;otacril;endecril;edecrina CBNumber: CB8215310 Molecular Formula: C13H12Cl2O4 Molecular Weight: 303.14 MDL Number: MFCD00056693 MOL File: 58-54-8.mol MSDS File: SDS TDS File: TDS Ethacrynic acid price More Price(52) Ethacrynic acid Chemical Properties,Uses,Production Description Ethacrynic acid is a loop diuretic with anticancer activity., It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC 50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM., Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC 50 s = 4.9 and ~0.4 M, respectively), and inhibits Wnt/-catenin signaling in a cell-based reporter assay

Antioxidant enzymes such as Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione Peroxidase (GPx) help to block the initiation of reactive species chain reactions and form the first line of antioxidant defence ( is transferred into H 2 O 2 via the addition of an electron in a reaction catalysed by SOD