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In the presence of 100 M TMAO, PNU37883A was able to reverse the loss of contractile function, consistent with a TMAO concentration-dependent role for inducing Kir6.1 channel potentiation in dampening the contractile function in cardiomyocytes

Kurpad, Krishna

5, nzaa179

10.1016/j.phrs.2009.02.004 203 YorkL

In other words, TMAO may indirectly enhance NF-B signaling by inhibiting SIRT1
