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The synergistic effect of nutritional-related metabolic syndrome on OA Beyond obesity alone, the constellation of nutrition-related metabolic syndrome (MetS) components including insulin resistance, dyslipidemia, and hyperglycemia, synergistically exacerbates OA progression through interconnected pathways

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At normal concentrations, ROS participate in many cellular and signaling pathways, including phagocytosis, enzyme activation, and cell cycle control (591)

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SA, NN, AA, JS, SH, DM, and NE wrote the manuscript

It is commonly studied in experimental settings focused on cellular regulatory systems and peptide-mediated signalling behaviour