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On reaction with hydrogen peroxide, the redox-sensitive cysteine residue of each subunit of PrxIII homodimer is oxidized to Cys-SOH, which then reacts with neighboring Cys-SH of the other subunit to form an intermolecular disulfide that can be readily reduced by Trx2 (18, 109)

doi: 10.3390/v13102056 278 LoweD

Antioxidant reduction of oxidative damage in the skin also contributes to a healthier overall appearance

[21] Traverso, N., Ricciarelli, R., Nitti, M., Marengo, B., Furfaro, A.L., Pronzato, M.A

Importantly, recent in vivo studies have shown that genetic inhibition of FSP1 alone is sufficient to induce ferroptosis and suppress tumor growth, even in the absence of GPX4 inhibition 80,81