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In general, three different groups of agents were described in the past: (i) mAbs, either targeting the ligand HGF or the receptor Met, (ii) tyrosine kinase inhibitors, targeting the tyrosine kinase domain of Met (and mostly also the TK domain of other RTKs), (iii) a truncated, soluble Met receptor serving as decoy for HGF (44) and the competitive HGF antagonist NK4 (18)

But by making that initial call globally, his action does however put him in the meritorious category of pioneer of a process which is now variously claimed as an achievement by many aspirants

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[DOI] [PubMed] [Google Scholar] 81.Van Cutsem E., Cervantes A., Adam R., Sobrero A., Van Krieken J.H., Aderka D., Aranda Aguilar E., Bardelli A., Benson A., Bodoky G., et al