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paracasei LMG-S-26420 viable counts were performed following the guidelines provided in the document ISTISAN Reports 2008/36, traditional microbiological methods and molecular methods for the analysis of food supplements based on or with probiotics for human use. For the Lactobacillus genus, this document specifies the use of MRS agar (BD, Difco, Italy) plates inoculated by spreading and incubating for 72 h at 37 C under anaerobic conditions

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1-3 Diagnoses of hyperpigmented lesions of the oral mucosa include physiologic melanin pigmentation, drug-induced skin pigmentation, oral melanocytic nevus, melanoma, black hairy tongue, oral melanoacanthoma, smoker's melanosis, amalgam tattoo, postinflammatory hyperchromia, and Laugier-Hunziker syndrome (pigmentation of the oral mucosa associated with melanonychia)

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19 Symptoms are usually of acute arthralgias occurring mainly in the shoulders, knees, and hands

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