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These are not "push through it" situations
Kottayam, India: Dee Bee Info Publications (2005)

For instance, Jomova et al (177) demonstrated that an excess of copper ions led to the aggregation of fatty proteins and abnormal expression of Fe-S cluster proteins, resulting in protein toxic stress and cell death

Journal of Clinical Endocrinology and Metabolism 91(3):799-805. [doi.org]
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Current treatments for gastroparesis include prokinetic agents that target neurotransmitter systems within the ENS
(PubMed) Hager K, Kenklies M, McAfoose J, Engel J, Munch G
