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The first agent to be tested clinically, tirapazamine, did not improve the activity of cisplatin and radiotherapy in randomized controlled trials, probably because it has poor diffusion characteristics into hypoxic regions

Small Molecule Activators of Clinical G6PD Variants Recently, we sought a structural chaperone that could correct the most common variants and identified one lead compound, AG1

[DOI] [PubMed] [Google Scholar] 135.Yusuf I.H., Foot B., Galloway J., Ardern-Jones M.R., Watson S.L., Yelf C., Burdon M.A., Bishop P.N., Lotery A.J

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A similar approach using HClO 4 and HPLC was used to extract GSH and GSSG from eight different species of edible mushrooms [39]