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In addition to IGF-1R, insulin-like growth factor binding proteins (IGFBPs) are required for IGF-1 bioavailability because they interact with IGF-1 with the same affinity as IGF-1R (41, 42)

Some protocols suggest treatments over several consecutive days to maximize uptake of the nutrient and receive the best overall benefit

The mechanism is proposed to involve G-protein coupled receptor signaling, but definitive identification of the functional receptor has not been published