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As a tyrosinase and PPO inhibitor, 4-HR is used as a food additive to prevent browning in fruits and shrimp melanosis (Arias et al

Feb 2018;21(1):12-15

Since most participants were ascertained in the latter two situations, the present cohort is a sicker, more-treatment-resistant population of CVS than is likely to be encountered by all but a few practitioners

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laboratory tests & amount of valproate ingested laboratory tests & amount of valproate ingested quantity of valproate ingested Careful: Dose dont always correlate well with clinical toxicity, so this may be falsely reassuring: Reported doses are frequently inaccurate