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In addition, DCA treatment alone caused ER stress to an extent that was nearly as robust as the bona fide ER stressor TM, as seen by splicing of Xbp1 (Figure 7F) and upregulation of UPR target genes (Figure 7G)

These metabolic benefits were sex-specific, with energy expenditure elevated in both male and female knockout mice

This is particularly important for drugs with a narrow therapeutic index or those that require specific blood concentrations to be effective

[DOI] [PMC free article] [PubMed] [Google Scholar] 220.Cheetham SC, Jackson HC, Vickers SP, Dickinson K, Jones RB, Heal DJ

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Shanghai Jiaotong Univ