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Moreover, the forbearance of transgenic lines toward different abiotic stresses such as cold, drought, salt, and heavy metals affirms its role in stress tolerance

Beyond its central role in apoptotic regulation, the tumor suppressor protein 53 (p53) critically contributes to ferroptosis by suppressing SLC7A11 expression

Bibcode:1989NYASA.570..514S

In hepatocellular carcinoma (HCC) studies, ADI-PEG-20 has been shown in early clinical trials to make HCC animal models and patients more sensitive to FOLFOX chemotherapy through arginine depletion

Acta 1790, 11491160

86 Subsequently, 3-phosphohydroxypyruvate is converted into serine by two sequential reactions catalysed by phosphoserine aminotransferase 1 and phosphoserine phosphatase