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doi: 10.1093/humupd/dmw025

ME-3 consumption leads to an increase of the reduced/oxidized glutathione ratio in the body, and to an overall improvement of oxidative status

The natural cycle also slows down due to environmental factors

Rossi M, Abdelmohsen K (2021) The emergence of senescent surface biomarkers as senotherapeutic targets
In macrophage and microglial models, fisetin was reported to downregulate iNOS, COX-2, and TNF-, while inhibiting the nuclear translocation of NF-B (p65) and phosphorylation of upstream kinases such as Src, Syk, and JNK [54,55,56]

W., Jellinger, K
