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H.VogelU.SullivanK.et al (2023)

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Of the two flavonoids, vicenin produced maximum reduction in percent aberrant cells while orientin and WR-2721 showed an almost similar effect.[] With respect to reducing the complex aberrations (dicentrics and rings) the cohort's receiving WR-2721 was observed to be the most effective followed by vicenin.[] In addition to the Ocimum flavonoids, studies have also shown that the nonpolar phytochemical eugenol [Figure 2] was also effective in preventing radiation-induced micronuclei in the bone marrow cells of mouse.[] Oral administration of different doses of eugenol (75300 mg/kg) before exposure to 1.5 Gy of gamma radiation caused a significant reduction in the frequencies of micronucleated polychromatic erythrocytes in the bone marrow cells, and the optimal dose was observed to be 150 mg/kg.[] In addition, the authors also observed that when compared to the concurrent radiation alone groups, administering 150 mg/kg of eugenol was also effective in preventing radiation-induced DNA damage when exposed to different doses of radiation (0.52 Gy) and also at various time point (2472 h) against 1.5 Gy-induced radiation.[] Studies with cultured human lymphocytes have also shown that rosmarinic acid, apigenin and carnosic acid (25 M) [Figure 2] have also been shown to prevent X-ray (2 Gy)-induced chromosomal damage.[] Tulsi enhances the bone marrow radioprotection WR-2721 Amifostine, a phosphorothioate that selectively accumulates in the normal tissue is agreeably the highly experimented radioprotector to date