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However, because this was a retrospective observational study, the findings cannot establish that higher semaglutide doses directly caused the improved cardiovascular outcomes, and unmeasured confounding factors may have influenced the observed associations

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1,2 Clinical trauma studies face the problem that the degenerative process, which is initiated by a traumatic event can take a long time to evolve which then may or may not become symptomatic with a new onset of pain and/or neurological symptoms
