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Lee MW, Bassiouni R, Sparrow NA, Iketani A, Boohaker RJ, Moskowitz C, et al

Ice crystal formation during freezing causes physical damage to the peptide structure that cannot be reversed
[DOI] [PubMed] [Google Scholar] 181

Cages were exchanged for new sanitized cages filled with irradiated bedding every 2 weeks

Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E

It is well-tolerated in animal and early clinical studies, even at multi-milligram doses [12]