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and (B) VMAT2-mediated exchange transport, in which amphetamine enters vesicles while monoamines are transported into the cytoplasm

Within cells (principally the liver where it is stored) the folic acid found in enriched food and in vitamin supplements is converted first to dihydrofolate (DHF) and then to tetrahydrofolate (THF also H 4 folate) through the action of dihydrofolate reductase, an NADPH-requiring enzyme

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This is the version responsible for neutralizing free radicals and supporting detox at the cellular level

Further, although antioxidant enzyme activity was not directly measured in this study, the cGMP-mediated upregulation of GPx-1 and catalase consequently enhanced protection against hydrogen peroxide-induced cell death (339)