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Campbell KJ, Tait SWG
J Hepatol 2003;38:51-58
This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD (Gu et al., 2013), which may impair the conversion of pyruvate to acetyl-CoA, leading to mitochondrial dysfunction and accumulation of lactate and alanine
El uso de topiramato se asocia a oligohidrosis, es decir, disminucin de la produccin de sudor asociada a hipertermia, lo que significa que los pacientes pierden el mecanismo normal de proteccin frente a hipertermia
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This process, known as beiging, converts white fat cells into cells capable of burning energy as heat rather than storing it
