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Glutathione deficiency impairs the body's ability to get rid of toxins whether they are environmental or the by-products of cellular metabolism

H., Kvietikova, I., Rolfs, A., Gassmann, M

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90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression