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In an earlier study, we treated juvenile rats with methylphenidate or amphetamine through the peripubertal period and discovered that the normal functional connections between the striatum, sensorimotor cortices and prefrontal cortex were reduced ( 9 -THC exposure and discontinuation on mice, awake or anesthetized, challenged with amphetamine

In vitro work using human articular chondrocytes showed dose-dependent increases in type II collagen synthesis and aggrecan (the major cartilage proteoglycan)

doi: 10.1196/annals.1332.007

Systemic anti-inflammatory signaling: TB-500 downregulates inflammatory cytokines across multiple tissue types, including muscle, tendon, cardiac, and neural tissue

8-week on, 4-week off example: Weeks 1-2: Assessment and dose finding (every other day) Weeks 3-6: Optimization phase (3-5 times weekly) Weeks 7-8: Maintenance (3 times weekly) Weeks 9-12: Complete break, no DSIP During the off period, focus on sleep hygiene fundamentals: consistent wake times, light exposure management, temperature optimization, and stress reduction

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