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Diabetes Care 42 , S124S138 (2019)

Common trial endpoints are (1) new gadolinium-enhancing T1-weighted lesions, (2) new or enlarging T2-weighted lesions, (3) annualized relapse rates, and (4) confirmed disability progression for 6 months

PCD : nasal NO, genetics, specialized ciliary studies (adult cases may be mild and missed by genetics alone)

A greater diversity has been identified to be associated with fewer IBS-like complaints (74)

In the Billon 2023 paper, mice given 30 mg/kg IP still showed measurable plasma and muscle concentrations at 6 hours post-injection, which helps explain why twice-daily dosing was used in efficacy studies

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