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Elias, P

To test this hypothesis experimentally, we created two truncated APOE M variants: (i) aggregation-prone APOE M -AP with truncated helices N1 and N2 (residues 1-23), and (ii) aggregation-suppressed APOE M -AS with the same truncation, but carrying additional four mutations (R38A, E45A, E49A, and R145A)

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No severe adverse effects have been consistently reported, which is important and makes taurine a safe long-term option for managing MELAS symptoms [57,69,70]