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The most common AEs reported during the study were: Headache (6 times) Fatigue (4) Hypoglycemia unspecified (3) Dizziness (3) Nasopharyngitis (2) Cough (2) Lethargy (1) Tonsillitis (1) Abdominal pain unspecified (1) Application site reaction unspecified (1) Injection site bruising (1) Rhinitis seasonal (1) Anorexia (1) Injection site pain (1) None of the AEs were of severe intensity and there was no observable trend between the different treatment groups with respect to the incidence of certain AEs

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The main function of the bicarbonate in the water is to act as buffer and minimize the pH fluctuation

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Other characteristic changes in disc herniation, particularly cell clustering and upregulation of matrix-degrading enzymes, may also be consequences of initial tissue disruption and swelling

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Less common issues include itching or a rash that may signal a mild allergic reaction, or brief dizziness

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