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Read review Dihexa for Cannabis & Weed Brain Fog The January 2025 JAMA Network Open working-memory fMRI study of 1,003 young adults (63% of heavy lifetime and 68% of recent users showing reduced dorsolateral/dorsomedial prefrontal and anterior-insula activity)

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This idea is supported by other neurodegenerative diseases experiencing severe localized copper deficiency, such as the motor neurons of ALS patients (Hilton et al., 2024), PD patients with up to 50% reduction of copper seen in the substantia nigra (Bisaglia and Bubacco, 2020), brain copper reductions in prion diseases (Sorenson, 2001), and notably Menkes disease which is characterized by an X-linked defect in copper transporting ATP7-A gene that leads to severe systemic copper deficiency and progressive neurodegeneration (Tmer and Mller, 2010)