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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

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Laboratory studies using chondrocyte cultures and animal models have investigated how the peptide influences pathways involved in extracellular matrix regulation and tissue repair [4]

Conversely, in another study, 615 patients with IGF-1 values in the lower half of the normal range were closely observed during 4.5 years

This depends on your degree of deficiency and individual response

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