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FIGURE 2 3 Redox dysregulation in disease states 3.1 GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface

Several recent studies have systematically examined these markers and monitored key targets regulating ferroptosis, confirming the presence of ferroptosis in hemorrhagic stroke diseases (Shao et al., 2019

doi: 10.1161/ATVBAHA.111.240341

Cell 75 , 620630.e629 (2019)

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Discussion Our results suggest that long COVID-derived brain fog is associated with BBB disruption and sustained systemic inflammation