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5 Future Directions, Gaps, and Needs Currently, much of ALS care focuses on symptomatic management using medications described above

This impairment results in increased apoptosis, particularly in renal proximal tubular cells, exacerbating kidney dysfunction [145]

ATP-binding cassette transporter A4 (ABCA4) facilitates the transport of atRAL from the outer segment discs of photoreceptors to the cytoplasm, while all-trans retinol dehydrogenase 8 (RDH8) catalyses the conversion of atRAL back to all-trans retinol (260)